Microfluidics-mediated spatial control of mRNA lipid nanoparticles primes translation and enhances vaccine potency
Nature Biomedical Engineering, 1-14
Peptide+ RNA/LNP Microfluidics
DRUG DELIVERY ENGINEERING LABORATORY
For precision delivery of RNA, therapeutics and bioactive molecules.
Led by Lei Zhang, PhD · Professor & Principal Investigator
We design peptide and lipopeptide building blocks, control their programmed assembly, and develop the resulting structures as delivery carriers for drugs, nucleic acids and bioactive molecules.
02We develop lipid- and peptide-enabled delivery systems for mRNA, siRNA and small-molecule therapeutics, with emphasis on carrier architecture, targeting and biological performance.
03We use microfluidic flow, interfacial effects and oscillatory shear to reprogram delivery-carrier architecture, control spatial organization and hierarchical loading, and enable reproducible, scalable manufacturing.
Nature Biomedical Engineering, 1-14
Stem Cell Reviews and Reports 22 (4), 1550-1567
Research 9, 1170
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